Database : HANSEN Search on : ANTIGENO DE MITSUDA/ADMIN [Subject descriptor] References found : 57 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 18329 Author: Fasal, P Title: Leprosy occurs everywhere ?- Source: San Francisco; s.n; 1965. 7p p. ilus. Abstract: Leprosy can occur at all ages, in both sexes and in every race. It can be found in any geographic area and can simulate many diseases, especially those affecting the skin. The lepromatous type indicates less host resistance than the tuberculoid type. Histopathologic examination of a properly stained specimen obtained by skin biopsy is the most important diagnostic procedure. Treatment consist of long-term chemotherapy with sulfone drugs. Descriptors: HANSENIASE/clas HANSENIASE/compl HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/imunol HANSENIASE/terap HANSENIASE/transm HANSENIASE DIMORFA/diag HANSENIASE TUBERCULOIDE/diag HANSENIASE VIRCHOWIANA/diag HANSENIASE/patol DAPSONA/admin DAPSONA/uso terap - DISTRIBUICAO ESPACIAL  ANTIGENO DE MITSUDA/admin  ANTIGENO DE MITSUDA/anal  BIOPSIA/util Limits: HUMANO Location: BR191.1; 00198/s

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Id: 18102 Author: Fernández, J. M. M Title: The early reaction induced by lepromin ?- Source: Rosario; s.n; 1940. 13p p. . Abstract: The intradermal reaction to lepromin has been studied in a total of 563 persons, cases of leprosy and contacts. Observation of its clinical and histopathologic development has shown the following facts:a- In allergic cases intradermal injection of lepromin induces an "early" reaction which is well defined, both clinically and histologically, beginning a few hours after injection and reaching its maximum between 48 and 72 hours, thereafter decreasing until it disappears completely during the first week. b- This early reaction, which is manifested clinically by an erythematous halo, usually infiltrated, is not of nonspecific character since it has the histologic structure common to allergic reactions and is only seen in those cases which offer resistance to the infection (i.e., neural forms of the disease, particularly the tuberculoid form) and does not occur in cases which are considered anergic, as in the lepromatous type...AU. Descriptors: ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/ef drogas ANTIGENO DE MITSUDA/uso diag - MODELOS ANIMAIS  MYCOBACTERIUM LEPRAE/cresc  MYCOBACTERIUM LEPRAE/patogen Limits: ANIMAL Location: BR191.1; 00716/s

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Id: 17162 Author: S. B. B. M. Dharmendra; N, Mukherji. Title: Prognostic value of the lepromin test. Source: Lepr Ind;18(3):80-87, july, 1946. tab. Abstract: 1. A study been made of the progress of the disease in relation to the results of the lepromin test, in 160 cases of leprosy (109 neural, 46 lepromatous, and 5 of doubtful classification) first tested six years ago. 2. the prognostic value of the test is best illustrated in cases of the neural type. Of the 109 cases of the neural type lepromin test was positive group, improvement was seen in about 84 per cent of the cases. In the disease becoming worse in only 14 per centin the lepromin-negative and doubtful group improvement was seenonly in 53 per cent of the cases the disease becoming worse in 47 per cent. In only one case has the disease changed from the neural to the lepromatous type, and this occurred in a lepromin-negative case. The degree of positivity of the test also influence the prognossis of the 92 lepromin-positive neural cases 20 had strongly positive 49 moderately positive and 23 weak positive reactions (AU). Descriptors: ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/uso diag ANTIGENO DE MITSUDA/isol Location: BR191.1

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Id: 17096 Author: S, B. B. M. Dharmendra; S. S. Jaikaria. Title: Studies of the lerpromin test. Results of the test with various antigens in non-contacts. Source: Lepr Ind;15(2):40-45, apr., 1943. . Descriptors: ANTIGENO DE MITSUDA/admin TESTES CUTÂNEOS/hist TESTES CUTÂNEOS/métodos MYCOBACTERIUM LEPRAE Location: BR191.1

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Id: 17018 Author: Fernandez, José M. M. Title: Sensitization to lepromin in presumably non-leprous individuals. Source: Int. J. Lepr;11(n.esp):15-22, Dec. 1943. . Abstract: The experiments which have been reported demonstrate that: 1- It is possible to sensitize presumably non-leprous persons to leprominby intradermal injection of either an oily or an aqueous suspension of Mycobacterium leprae killed by hat. Furthermore, this sensitization ensues in a high percentage of subjects. 2- Sensitization to lepromin can be produced also by intradermal injection of suspensions of Mycobacterium tuberculosis killed by heat. This is in agreement with the opinion which we have expressed (10,11) in discussing positive lepromin reactions in patients with cutaneous tuberculosis and in persons who had been vaccinated with B.C.G. 3- The early lepromin reaction is attributable to previous intradermal injection of purified lepromin protein (L.P.P.), nor by injection of a suspension of E. typhosus killed by heat. 5- As regards the duration of sensitivity to lepromin, a final answer cannot be given. We have observed positive early reactions to the antigen L.P.P. in presumably non-leprous individuals who have received endermal injections of integral lepromin five years previously. 6- As to the practical value of allergic response as an element of protection against later infection, we believe that it is more desirable for an individual exposed to leprosy to have a positive lepromin reaction. Unfortunately it is not possible to provoke this supposedly protective allergy, since apparently it is dependent on an unknown factor which may be constitutional. When that factor is lacking, nothing can be gained by the intradermal injection of the antigen. However, if the factor is present in an individual as evidency by his capacity to reactin an allergic manner to the antigen, we believe that he will always have a high degree of immunity to leprosy, regardless of his previous state os sensitization.(AU). Descriptors: ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/isol ANTIGENO DE MITSUDA/imunol Limits: HUMANO Location: BR191.1

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Id: 16556 Author: Wade, H. W. Title: The lepromin reaction in normal dogs; preliminary report. Source: Int. J. Lepr;9(1):39-56, Jan.-Mar. 1941. tab, graf. Abstract: 1- In this preliminary communication it is shown that the finding of Rodriguez that the dog reacts positively to intracutaneous injection to lepromin has been confirmed and extended. this animal, therefore, offers a convenient medium for the study of this and other reactions of the general Mitsuda type. 2- From a summarization of the data ot ten previously unmolested animals, comprising indivudulas of an extreme range of reactivity, a "normal average" curve of the course of the reaction has been constructed. 3- The principal features of this curve are: an inmediate nonspecific edematous reaction, followed by recession by resorption, usually for two days; a period of latency, of highly variable lenght but usually lasting about seven days, during which a banal foreign-body lesion may be present and which is ended by onset of the definitive reaction; and, finally, three phases of the latter: primary development, height of activity and recession. 4- It is noted, without the supporting data that the factors of original dosage (number of injections), early reinjections (of the same or other antigens) and surgical intervention (multiple biopsies) with secondary inflammation, have no apparent influence on the time of onset or on the primary phase of development of the positive reaction. Reinjections may have a disturbing effect in the relatively unstable second period, but not materially in the recessive stage. The fact that the site of injection influences to some extent the degree of reactions is also noted. 5- Indications have been seen that the condition which ensues in animals given few injections is less stable as regards fluctuations in the course of the reaction than in those given massive total dosages, and also that it may be naturally less stable in prompt, vigorous reactors than in slow ones. The question of whether or not dogs from a highly leprous community may react more vigorously than others cannot be answered. 6- It is concluded that this reaction, while undoubtedly one of allergic nature, is not a test of the existence of allergic hypersensitiveness, but rather one of capability in lepromatous cases. Mention is made of certain peculiarities of it, as seen in its practical application, thatrequire elucidation. (AU). Descriptors: ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/anal ANTIGENO DE MITSUDA/imunol Limits: CAES Location: BR191.1

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Id: 16519 Author: Guinto, R. S; Wade, H. W. Title: Results of tests with serial dilutions of lepromin in separate groups of normal young children with a comparison of two lepromins and the Dharmendra antigen. Source: Int. J. Lepr;26(4):328-345, Oct.-Dec. 1958. tab, graf. Abstract: To ascertain whether or not high dilutions of lepromin would be practical for the field testing of normal populations, two series of tests were made with healthy schoolchildren aged 6-9 years. The first series comprised five groups averaging 116 children each, all of Opon poblacion (town), the second one five groups averaging 92 each, all of outlying barrios (rural villages). None had been lepromin tested before or BCG vaccinated, and none was given more than one injection of lepromin. In the first series two lepromins made by different methods (M, by Mabalay, and W, By Wade) were compared with each other and with the Dharmendra antigen, and two dilutions (1/10 and 1/20) of the stock W lepromin were also used. The tests in the second series were with five concentrations of the W lepromin: 1/1 (i.e., undiluted), 1/10, 1/20, 1/40 and 1/80. With respect to the late reaction, the two lepromins in Series 1 gave the same results, 75 per cent positives. The M stock, however, elicited fewer early reactions than the W stock, suggesting that boiling may be less effective than autoclaving in freeing the soluble antigenic elements involved in that reaction. In series 2 the full-dose W lepromin gave rise to more positive reactions of both kinds than it had in Series 1, and the dilutions gave increasingly large differences with respect to the late reaction. The Dharmendra antigen proved ineffective in eliciting either type of response in these very young and immature subjects, this result with the late reaction probably due to the extraction of the lipids during manufacture....(AU). Descriptors: HANSENIASE/clas HANSENIASE/diag ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/ef adv Limits: ESTUDO COMPARATIVO CRIANÇA Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 16444 Author: Ermakova, N. I. Title: The histopathology of the reactive phase of lepromatous leprosy. Source: Int. J. Lepr;8(2):159-166, Apr.-Jun. 1940. ilus. Descriptors: HANSENIASE/imunol HANSENIASE/patol ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/anal Limits: HUMANO Location: BR191.1

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Id: 16423 Author: Lara, C. B. Title: Mitsuda's skin reaction (lepromin test) in children of leprous parents. II. Observations on newly-born to eighteen-month-old children. Source: Int. J. Lepr;8(1):15-28, Jan.-Mar. 1940. tab. Abstract: One hundred and ten unisolated nonleprous children of leprous parents, ranging in age from newly-born to eighteen months, all closely observed since birth, were given the lepromin test repeatedly at intervals of four months, with special attention to the appearance of early, recognizable lesions of leprosy, and the results of the tests were analyzed and correlated with the clinical observations. Sex was found to have on the lepromin reaction. The frequency of positive reactions was in direct relation to the age, a small but not negligible proportion of undoubtedly positive reactions accurring, in the first test, among the children less than one year old. In the retests there was a further progressive increase in the proportion of positive reactors which could not wholly be attributed to further ageing, but was probably in part the effect of retesting. Thus a majority of the children who were still less than one year old gave definitely positive reactions in the second or third test. Retesting of strongly positive reactors with a markedly reduced dose of lepromin more frequently resulted in a distinctly diminished reaction in the absence of manifest leprosy than when lesions were already in evidence. The appearance or existence of early leprotic lesions in the children was associated with an apparently undiminished, and possibly even greater tendency to react positively to the test. Both the duration and the constancy of exposure to leprous environment seemed also to bear a direct relation to the proportion of positive reactions.Intercurrent disease not of a serious nature showed no depressing influence on the reaction. (AU). Descriptors: HANSENIASE ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/ef adv ANTIGENO DE MITSUDA/imunol Limits: HUMANO Location: BR191.1

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Id: 16422 Author: Fernández, José M. M. Title: The early reaction induced by lepromin. Source: Int. J. Lepr;8(1):1-14, Jan.-Mar. 1940. ilus, tab. Abstract: The intradermal reaction to lepromin has been studied in a total of 563 persons, cases of leprosy and contacts. Observation of its clinical and histopathologic development has shown the following facts: (a) In allergic cases intradermal injection of lepromin induces an "early" reaction which is well defined, both clinically and histologically, beginning a few hours after injection and reaching its maximum between 48 and 72 hours, thereafter decreasing until it disappears completely during the first week. (b) This early reaction, which is manifested clinically by an erythematous halo, usually infiltrated, is not of nospecific character since it only seen in those cases which ofter resistance to the infection (i.e., neural forms of the disease, particularly the tuberculoid form) and does not occur in cases which are considered anergic, as in the lepromatous type. (c) In 95 percent of cases the early reaction coincides with the late nodular reaction in the 3rd week (the classical Mitsuda reaction). (d) The early and late reactions are probably brought about by different substances or toxins of the Hansen bacillus, since a filtrate of lepromin always gives the early reaction in allergic cases whereas only exceptionally does it cause a faint late reaction. (e) When the filterable toxins of the Koch bacillus (tuberculin) and the total toxins of the same (suspension of the bacillus killed by heat) are injected intradermally into lepers, the former only induces an early reaction whereas the latter induces both this reaction and a late one, consisting of a nodule or papule, in the third week. (f) THe previous experiment gives rise to the supposition that, like the Koch bacillus, that of Hansen contains soluble toxins which can be separated from the bacillary organism and insoluble toxins which cannot be thus disassociated, both being capable of producing allergic reactions in sensitized individuals. (g) The early reaction induced by lepromin resembles, clinically and histologically, the Mantoux reaction. Nevertheless, in a comparative study of both reactions in a group of lepers and contacts, the results did not agree in 45 percent of cases. (AU). Descriptors: ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/clas ANTIGENO DE MITSUDA/imunol HANSENIASE/clas HANSENIASE/patol Location: BR191.1

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Id: 16407 Author: Bechelli, Luiz Marino. Title: The influence of repeated lepromin testing on the Mitsuda reaction in healthy people. Source: Int. J. Lepr;27(3):228-235, July-Sept. 1959. tab. Abstract: Inyecciones repetidas de lepromina pueden ocasionar positivización de la reacción de Mitsuda o intensificación de la misma en reactores débilmente positivos. Resulta por lo tanto indispensable tener un grupo testigo en los experimentos con BCG u otras vacunas administradas a fin de acrecentar la resistencia. No hay todavía suficientes datos para demonstrar que las inyecciones repetidas de lepromina acrecienten la resistencia contra la lepra. (AU). Descriptors: HANSENIASE HANSENIASE/clas HANSENIASE/diag ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/clas Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 16248 Author: Gehr, E. Title: The Mitsuda reaction with the Dharmendra antigen in various groups of healthy persons in Surinam. Source: Int. J. Lepr;23(4):393-399, Oct.-Dec. 1955. mapas, tab. Abstract: In an extension of previous work, a total of 1,499 persons in Surinam have been tested with the Dharmendra antigen, the dose 0.05 cc. These people comprise eight groups, four of them predominantly Creole, the others East Indians, Indonesians, Bush Negroes and American Indians. The leprosy rates among these ethnic groups vary from 2.1 per cent for the Creoles (in total) to less than 0.3 per cent for the last two groups, although there may perhaps be more leprosy among these bush-country people than is known. The results of the lepromin tests show anomalous features in considerations of the leprosy rates and other circumstances, although the total figures are affected by different proportions of children in the different groups. Frequency of positive reactions does not increase with decrease pof the frequency of leprosy, but rather the opposite. The Creoles as sampled, representing a group among whom the frequency of the disease is high, gave in total 63 per cent positives (adults 72 per cent) despite the high frequency of the disease among them. The distantly-located Bush Negroes, with relatively little known leprosy, gave 70 per cent positives in total, and as high as 81 per cent for one lot of adults. Other unexpected results are noted. (AU). Descriptors: HANSENIASE HANSENIASE/etnol ANTIGENO DE MITSUDA ANTIGENO DE MITSUDA/admin Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 16231 Author: McKinley, Earl B. Title: The present status of diagnostic skin tests in leprosy. Source: Int. J. Lepr;6(1):33-46, Jan.-Mar. 1938. tab. Descriptors: HANSENIASE HANSENIASE/diag ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/ef drogas ANTIGENO DE MITSUDA/imunol Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 16197 Author: S, B. B. M. Dharmendra. Title: Studies of the lepromin test, A bacillaryu antigen standardised by weight. Source: Lepr Ind;14(4):122-129, oct., 1942. . Abstract: I. A method of preparing standard lepromin dried and partly defatted leprosy bacilli is described. The bacilli are obtained by extracting the nodules with chloroform, evaporating the chloroform extract, suspending the resudue in ether and centrifugalising the ethereal suspension in cold. The standardisation is done by weight of the bacterial powder, I mg. of the powder being suspended in 10 c.c. of carbol-saline, and 0.1 c.c. of suspension being used for the test 2. This preparation, like the ordinary lepromin prepared directly form the leprous tissue, produces both early and late reactions in the cases of the neural type of leprosy and no reactions, early or late in case of the lepromatous Type. However, with this preparation the early reactions are stronger, and the late reactions considerably weaker than corresponding, reactions pruduced by ordinary lepromin. This is considered to be an advantage (AU). Descriptors: ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/quim ANTIGENO DE MITSUDA/isol HANSENIASE Location: BR191.1

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Id: 16152 Author: Lowe, John; S, B. B. Dharmendra. Title: Studies of the lepromin *test. Source: Lepr Ind;12(4):121-137, oct., 1940. . Descriptors: ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/uso diag ANTIGENO DE MITSUDA/hist ANTIGENO DE MITSUDA/isol Location: BR191.1

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Id: 16110 Author: Doull, James A; Guinto, Ricardo S; Mabalay, Mario C. Title: Effect of BCG vaccination, lepromin testing and natural causes in inducing reactivity to lepromin and to tuberculin. Source: Int. J. Lepr;25(1):13-37, Jan.-Mar. 1957. tab, graf. Abstract: 1- A report is made of an effort to determine the relative importance of natural causes, initial lepromin testing, and vaccination with BCG in producing reactivity to lepromin and to tuberculin. The possibility is admitted that the final lepromin test may itself cause reactivity of the Mitsuda type but there is no available means of separating this efffect from that of natural causes. 2- The subjects were 550 apparently healthy children, 6 months to 35 months of age, having no known contact with leprosy, living in their homes on Mactan Island, Cebu, Philippines, of whom 483 completed all requirements of the study. 3- A random sample of one-fifth constituted a basic control group, given initially only a tuberculin test (PPD-S, 0.0001 mgm.). The remainder were tested with lepromin and PPD-S, and those negative to both were divided at random into four subgroups. Two were vaccinated intradermally with BCG, one with a fresh preparation and the other with a lyophilized one. The other subgroups were given diphtheria toxoid and saline, respectively. Ninety to 100 days after the BCG and other inoculations, and, on the average, 143 days after the initial tests, all children including the basic controls were tested with lepromin and PPD-S of the same lots, and in the same dosages, as those used at the outset...(AU). Descriptors: HANSENIASE HANSENIASE/clas HANSENIASE/diag ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/ef adv HANSENIASE/prev Location: BR191.1

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Id: 15939 Author: Dharmendra; Chatterjee, K. R. Title: Prognostic value of the lepromin test in contacts of leprosy cases. Source: Int. J. Lepr;24(3):315-318, July-Sept. 1956. tab. Descriptors: HANSENIASE HANSENIASE/clas HANSENIASE/diag ANTIGENO DE MITSUDA/admin Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 15936 Author: Floch, H. Title: Sur la reaction de Mitsuda intraderm-reaction a l'aide d'extrait phenique de peau normale. Source: Int. J. Lepr;24(3):292-296, July-Sept. 1956. tab. Abstract: The author points out that the classical Mitsuda-Hayashi lepromin is a complex of bacilli, leprous tissue, and normal skin tissue. The bacillus is the only specific element, and nonreactivity of lepromatous cases is the only specific result of the test. Suspensions of leprosy lesions without bacilli (tuberculoid; Fernandez), and of normal skin (de Faria, Kooij) have been reported to cause Mitsuda-type reactions in some nonlepromatous cases. This report is of results obtained with the latter type of preparation, comparing the author´s 1:750 dilution of lepromin with a 1:40 suspensions of normal skin. In the 12 lepromatous cases tested, both of the antigens caused a few positive early reactions, but somewhat more than one-half of the 145 other leprosy cases tested (indeterminate and tuberculoid) gave such reactions to the normal-skin suspension but less than one-half of them to the dilute lepromin. As for theb late reactions in these cases, the normal-skin suspension gavve them a little over 50 per cent, and the lepromin dilution caused 72 per cent among the indeterminate and 90 per cent in the tuberculoid cases. (AU). Descriptors: HANSENIASE HANSENIASE/clas HANSENIASE/diag ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/ef adv Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 15910 Author: Kooij, R; Gerritsen, Th. Title: Positive "lepromin" reactions with suspensions of normal tissue particles. Source: Int. J. Lepr;24(2):171-181, Apr.-June, 1956. tab. Abstract: 1- Positive early and "lepromin" reactions have been obtained with suspensions of normal skin and of normal liver particles in patients with tuberculoid leprosy. These suspensions gave negative results in patients with lepromatous leprosy. 2- The results of the experiments support the hypothesis that in the Mitsuda reaction we are dealing with a foreign-body reaction. 3- Besides the particles of normal tissue, the leprosy bacilli may also act as foreign bodies, due to the fact that they are not broken down readily. 4- If the assumption is correct that the Mitsuda reaction is a foreign- body reaction, then it is incorrect to attempt to prove any immunological relationship between leprosy and tuberculosis by means of this reaction. 5- Active lepromin was also prepared from lepromatous liver and spleen. (AU). Descriptors: HANSENIASE ANTIGENO DE MITSUDA/admin Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 15881 Author: Ignacio, José L; Palafox, Clarina A. Title: Mitsuda reactions induced by repeated lepromin testing in children removed at birth from their leprous parents. Failure of BCG to induce strong reactivity in persistently moderate reactors. Source: Int. J. Lepr;23(3):259-269, July-Sept. 1955. tab. Abstract: Preséntase una reseña de la reactividad de Mitsuda provocada por la comprobación repetida con lepromina. Los sujetos fueron 50 niños pequeños residentes en la Leprosería de Culión que, con una excepción, habían sido separados al nacer de los padres leprosos. La excepción era un niño que no había estado expuesto a la madre más que algunas horas. En todos se usó el mismo repuesto de lepromina. Como positiva se consideró una reacción de 3 5 mm. o mayor a partir de la tercera semana. Se hicieron cuatro pruebas en todo el grupo: septiembre-octubre, 1949; noviembre, 1949; mayo, 1950; y septiembre-octubre, 1950. La quinta comprobación se hizo en marzo de 1951, pero solamente en 32 niños, todos con reacciones de 2+, para ver si podían inducirse respuestas más intensas. La prueba final se hizo en diciembre de 1951, unos dos años y cuarto después de la primera prueba, en los 47 niños todavía accesibles. En la primera prueba, sólo 22 por ciento resultaron positivos, comparados con 72.7 por ciento observado por Lara hace algunos años en Culión en 110 niños pequeños que no habían sido separados de los padres leprosos. Al repetirse las pruebas, lo mismo que sucedió en la serie de Lara, hubo un aumento gradual en la proporción que reaccionaba, de modo que en la tercera prueba 96 por ciento reseultaron rreactores, comparado con 99 por ciento en el grupo de Lara. En la cuarta prueba, reaccionaron todos los niños de la serie actual. Muchos de los niños obtuvieron reactividad y mostraron reacciones intensas, aunque tenían menos de un año de edad. Se observó, según ya han descrito otros, activación de sitios antes negativos o de poca reacción. Después de la sexta prueba con lepromina, restaban 12 ninõn cuyas reacciones no habían pasado del grado de 2+. Diez de éstos, que eran negativos a la tuberculina, fueron vacunados con BCG en abril de 1952, y todos los 12 en julio de 1952, con la técnica de la multipunción. Dos meses después, al aplicarse una séptima prueba de la lepromina a estos niños, la reacción no había aumentados a más de 2+ en ninguno de estos niños. (AU). Descriptors: HANSENIASE HANSENIASE/clas HANSENIASE/diag ANTIGENO DE MITSUDA/admin ANTIGENO DE MITSUDA/clas Limits: CRIANÇA Electronic Medium: http://www.ilsl.br Location: BR191.1

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